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The brand new pheomelanin ring from the agouti-patterned hairs is caused by a pulse of ASIP term throughout the growth of hair, leading to a key out of eumelanin to pheomelanin creation. To determine the effectation of p.H587Y to your CORIN’s intent behind managing ASIP on the tiger, we transfected HEK293 cells with tiger ASIP and you will/or CORIN variations. No differences try thought of between your term amount of wild-kind of CORIN and the p.H587Y mutant inside the muscle (Profile 1F, remaining committee).
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